Eran Bacharach's Lab
for Molecular Virology
![](https://static.wixstatic.com/media/caf3c8_cd81f10bbb384a02a41438e37ccdff5a~mv2.png/v1/fill/w_118,h_52,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/caf3c8_cd81f10bbb384a02a41438e37ccdff5a~mv2.png)
Selected Publications
Cohn O, Yankovitz G, Mandelboim M, Peshes-Yaloz N, Brandes R, Bacharach E, Gat-Viks I. The host transcriptional response to superinfection by influenza A virus and Streptococcus pneumoniae. mSystems. 2024 Apr 16;9(4):e0104823.
Barer L, Schröder SK, Weiskirchen R, Bacharach E, Ehrlich M. Lipocalin-2 regulates the expression of interferon-stimulated genes and the susceptibility of prostate cancer cells to oncolytic virus infection. Eur J Cell Biol. 2023 Jun;102(2):151328.
Karniely S, Faigenboim A, Watted S, Lapin K, Berenshtein E, Hurvitz A, Bouznach A, Rozenblut E, Orioles M, Galeotti M, Salinas I, Berkowitz A, Bacharach E, Eldar A. Discovery of an unrecognized nidovirus associated with granulomatous hepatitis in rainbow trout. iScience. 2023 Mar 11;26(4):106370.
Abu Rass R, Kembou-Ringert JE, Zamostiano R, Eldar A, Ehrlich M, Bacharach E. Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification. Front Cell Dev Biol. 2022 Dec 16;10:1075364.
Cohn O, Yankovitz G, Peshes-Yaloz N, Steuerman Y, Frishberg A, Brandes R, Mandelboim M, Hamilton JR, Hagai T, Amit I, Netea MG, Hacohen N, Iraqi FA, Bacharach E, Gat-Viks I. Distinct gene programs underpinning disease tolerance and resistance in influenza virus infection. Cell Syst. 2022 Dec
21;13(12):1002-1015.e9.
Abu Rass R, Kustin T, Zamostiano R, Smorodinsky N, Ben Meir D, Feder D, Mishra N, Lipkin WI, Eldar A, Ehrlich M, Stern A, Bacharach E. Inferring Protein Function in an Emerging Virus: Detection of the Nucleoprotein in Tilapia Lake Virus. J Virol. 2022 Mar 23;96(6):e0175721.
Ehrlich M, Bacharach E. Oncolytic Virotherapy: The Cancer Cell Side. Cancers (Basel). 2021 Feb 24;13(5):939.
Dellac S, Ben-Dov H, Raanan A, Saleem H, Zamostiano R, Semyatich R, Lavi S, Witz IP, Bacharach E, Ehrlich M. Constitutive low expression of antiviral effectors sensitizes melanoma cells to a novel oncolytic virus. Int J Cancer. 2021 May 1;148(9):2321-2334.
Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I. Cell composition analysis of bulk genomics using single-cell data. Nat Methods. 2019 Apr;16(4):327-332.
Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L, Cohn O, David E, Frishberg A, Mayo L, Bacharach E, Amit I, Gat-Viks I. Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing. Cell Syst. 2018 Jun 27;6(6):679-691.e4.
.
Danziger O, Pupko T, Bacharach E, Ehrlich M. Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. Front Immunol. 2018 Jan 30;9:94.
NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Diab M, Glasner A, Isaacson B, Bar-On Y, Drori Y, Yamin R, Duev-Cohen A, Danziger O, Zamostiano R, Mandelboim M, Jonjic S, Bacharach E, Mandelboim O. Eur J Immunol. 2017 Apr;47(4):692-703.
Danziger O, Shai B, Sabo Y, Bacharach E, Ehrlich M. Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. Oncotarget. 2016 Aug 9;7(32):52115-52134.
Bacharach E, Mishra N, Briese T, Zody MC, Kembou Tsofack JE, Zamostiano R, Berkowitz A, Ng J, Nitido A, Corvelo A, Toussaint NC, Abel Nielsen SC, Hornig M, Del Pozo J, Bloom T, Ferguson H, Eldar A, Lipkin WI. Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. mBio. 2016 Apr
5;7(2):e00431-16.
Elis E, Ehrlich M, Bacharach E. Dynamics and restriction of murine leukemia virus cores in mitotic and interphase cells. Retrovirology. 2015 Nov 14;12:95.
Eyngor M, Zamostiano R, Kembou Tsofack JE, Berkowitz A, Bercovier H, Tinman S, Lev M, Hurvitz A, Galeotti M, Bacharach E, Eldar A. Identification of a novel RNA virus lethal to tilapia. J Clin Microbiol. 2014 Dec;52(12):4137-46.
Elis E, Ehrlich M, Prizan-Ravid A, Laham-Karam N, Bacharach E. p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes. PLoS Pathog. 2012 Dec;8(12):e1003103.
Nachmias D, Sklan EH, Ehrlich M, Bacharach E. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. Retrovirology. 2012 Jan 19;9:7.
Sabo Y, Ehrlich M, Bacharach E. The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production. J Virol. 2011 Jul;85(13):6594-609.
Prizan-Ravid A, Elis E, Laham-Karam N, Selig S, Ehrlich M, Bacharach E. The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex. PLoS Pathog. 2010 Nov 11;6(11):e1001183.
Sabo Y, Laham-Karam N, Bacharach E. Basal budding and replication of the murine leukemia virus are independent of the gag L domains. J Virol. 2008 Oct;82(19):9770-5.
Laham-Karam N, Bacharach E. Transduction of human immunodeficiency virus type 1 vectors lacking encapsidation and dimerization signals. J Virol. 2007 Oct;81(19):10687-98.
Mark-Danieli M, Laham N, Kenan-Eichler M, Castiel A, Melamed D, Landau M, Bouvier NM, Evans MJ, Bacharach E. Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity. J Virol. 2005 Jun;79(12):7756-67.
Melamed D, Mark-Danieli M, Kenan-Eichler M, Kraus O, Castiel A, Laham N, Pupko T, Glaser F, Ben-Tal N, Bacharach E. The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol. 2004 Sep;78(18):9675-88.